It's a common fact that DVD has made it affordable for people to obtain full seasons of their favorite shows, but for every show that makes it to DVD (some that I personally question) some can't seem to break through for various reasons.
What show would you like to see on DVD? Here are mine:
Rocko's Modern Life
I miss the early Nickelodeon days when Rocko, Heffer, Filbert and Spunky clashed with Mr. & Mrs. Bighead, homicidal kitchen appliances, and Flecko the fly. The screech of Dr. Hutchison hook hand across surfaces, the sound of her neck cracking, a ever changing profession and eventual marriage to Filbert always made me laugh. Unfortunately, the show is hardly on and Nick is terrible at releasing things on DVD unless it's Spongebob (I was surprised to see Invader Zim on DVD at all but I think it has a pretty strong cult following.)
Don't get this confused with the SNL sketches; this was a separate show on Comedy Central. It lasted one season and from what I've been able to dig up each episode exists on VHS but not on DVD. I still laugh when I think of the Anipals (a group of animal puppets) getting high off of "Christmas Cheer" which they forcefully extract from the spine of the show's overly-chipper host and get addicted to it.
Upright Citizens Brigade Season 2 & 3
Comedy Central released the first season and I immediately snatched it up but the release of the other seasons was based on the sale of the first season which probably didn't do so hot. The concept is hit and miss depending on who is watching but the sketch comedy of the Upright Citizen Brigade in their mission to undermind the status quo through the proliferation of chaos was bizarre enough to me to stand out.