According to Vicks: "Alcohol warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take acetaminophen or other pain relievers/fever reducers. Acetaminophen may cause liver damage.
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"When using this product:
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- Avoid alcoholic drinks.
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- Alcohol, sedatives, and tranquilizers may increase drowsiness.
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"Overdose warning: Taking more than the recommended dose can cause serious health problems. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children, even if you do not notice any signs or symptoms."
In checking the FAQs I see no explanation regarding mixing alcohol (which is Nyquil's main ingredient) with Nyquil. Heh, if you are counting carbs be warned that Nyquil liquid formula contains carbs, but the LiquiCaps do not.
Elsewhere: "aken in doses greater than 150 mg/kg/24 hr (>10 g), acetaminophen is a well-recognized cause of acute liver failure. This is a dose-dependent phenomenon, and the potential for hepatotoxicity after acute overdose is best predicted from an acetaminophen level plotted against the time that has elapsed since ingestion (Rumack-Matthew nomogram) (1).
Chronic moderate to heavy alcohol use potentiates the toxic effects of acetaminophen. Reports in recent years have drawn attention to the development of acute toxic effects on the liver in long-term alcohol users who have ingested acetaminophen, with therapeutic intent, in doses generally considered to be nontoxic (<10 g/24 hr) (2-6). Severe hepatotoxicity may occur after ingestion of as little as 4 g in 24 hours. This phenomenon is referred to as the alcohol-acetaminophen syndrome.
The incidence of the syndrome is unclear, although Lee (4) speculates that it may be the most common cause of acute liver failure in the United States. The paucity of reported cases is surprising, particularly considering that 31% of alcoholic persons use acetaminophen regularly, often daily, and that 1 in 10 of them abuses the drug (7). Thus, the extent of this association remains either poorly appreciated or underreported."
The article has much more on this: http://www.postgradmed.com/issues/2000/ … aganov.htm